Resources for Medical Professionals

The evidence linking the mouth to the rest of the body, organized for your practice.

A curated library of peer-reviewed studies on the oral-systemic connection, grouped by condition so you can find what is relevant in seconds. Plus a patient dental-health assessment form you can download and use in your own practice today.

40+peer-reviewed sources, curated and organized
9condition areas, from cardiovascular to respiratory
1patient assessment form, free to use in your practice

Use It Monday Morning

The patient dental-health assessment form

A short, plain-language form your patients can complete in the waiting room. It surfaces the signs of oral infection that rarely come up in a fifteen-minute visit, and it gives you a simple reason to start the oral-systemic conversation. Print it, add it to your intake packet, or hand it to a patient on the way out.

Free to use and share. No account required.

The Evidence

Peer-reviewed research, grouped by condition

Every source below was reviewed before it was added. Open a condition to see the studies. Each entry names the source and summarizes what it examines, and the association it describes is exactly that, an association that continues to be studied.

General & Foundational8 sources
AAOSHProfessional academy
The American Academy for Oral & Systemic Health, a hub of clinicians and researchers focused on the mouth-body connection and continuing education.
View source
U.S. Surgeon GeneralFederal health report
Oral Health in America, the Surgeon General's report establishing oral health as inseparable from overall health.
View source
Mayo ClinicClinical overview
Oral health as a window to overall health, a plain-language clinical overview of how oral bacteria and inflammation relate to conditions throughout the body.
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ScienceDirectReview article
Oral infections and systemic disease, a review describing oral infection as an emerging problem in medicine.
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Periodontology 2000Peer-reviewed review
A multimodal look at how periodontal disease relates to systemic diseases across special populations.
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The Stockholm Study30-year cohort
More than thirty years of observation on the effect of oral infections on systemic health.
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CDCPublic health perspective
The Oral Health in America report examined from a public health research perspective.
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NIH / NIDCRExecutive summary
Oral Health in America, advances and challenges, the NIH executive summary on the state of the field.
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Cardiovascular8 sources
Harvard Medical SchoolClinical overview
Gum disease and heart disease, the common thread, on the shared inflammatory pathway between the two.
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NIHJournal review
A review of the link between periodontal disease and cardiovascular disease.
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Ann. Periodontol.Journal
P. gingivalis induces foam cell formation and plaque rupture markers linked to cardiovascular disease.
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ScienceDailyResearch summary
On the connection between mouth bacteria and inflammation in heart disease.
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BMJ Postgrad Med JJournal review
How high-risk periodontal pathogens may contribute to the pathogenesis of atherosclerosis.
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Cleveland ClinicClinical overview
Oral health and the risk for cardiovascular disease, a patient-facing clinical explainer.
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AHA HypertensionJournal
Poor oral health and blood pressure control among U.S. adults with hypertension.
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Does Oral Health Affect Your Heart?Video
A short expert overview of the cardiovascular link between oral health and heart disease.
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Diabetes2 sources
NIHJournal review
Periodontitis and diabetes as a two-way relationship, where each condition appears to influence the other.
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American Diabetes AssociationJournal review
Diabetes and periodontal infection, and how each one makes the other harder to control.
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Stroke7 sources
AHA (JAHA)Journal
Oral bacterial signatures found in cerebral thrombi of patients with acute ischemic stroke who underwent thrombectomy.
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StrokeJournal
Periodontal disease examined as a risk factor for ischemic stroke.
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NIHJournal
Gingivitis and periodontitis as a risk factor for stroke in an Iranian population.
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NeurologyJournal
The combined effect of tooth decay and gum disease on ischemic stroke risk.
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NeurologyJournal
Periodontal disease independently associated with white matter hyperintensity volume.
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MedscapeClinical commentary
A summary of evidence linking gum disease to stroke risk for clinicians.
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PubMedMeta-analysis
An analysis of the association between periodontal disease and stroke.
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Alzheimer’s & Cognition3 sources
NIHJournal review
Periodontitis and Alzheimer's disease as a possible comorbidity linking chronic oral inflammation and neuroinflammation.
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ScienceDailyResearch summary
On a link between gum disease and cognitive decline in people with Alzheimer's.
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ScienceAlertResearch summary
Coverage of a study proposing that an oral pathogen may play a role in Alzheimer's disease.
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Pregnancy5 sources
Am. Family PhysicianJournal review
Oral health during pregnancy, a practice-oriented review for primary care.
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ScienceDirectJournal review
Periodontal disease and pregnancy outcomes, covering exposure, risk, and intervention.
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News-MedicalOverview
An overview of periodontitis and pregnancy for clinicians and patients.
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VIC Gov (Australia)Gov guidance
Government guidance on pregnancy and teeth, including what dental care is safe during pregnancy.
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DentaidPresentation
A slide overview of periodontal disease and pregnancy.
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Rheumatoid Arthritis6 sources
BMC Arthritis ResJournal review
On the association between rheumatoid arthritis and periodontal disease.
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NIHJournal review
Evidence accumulating for complex pathobiologic interactions between periodontal disease and rheumatoid arthritis.
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Arthritis FoundationOrganization
Guidance connecting rheumatoid arthritis and gum disease for patients and providers.
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NRAS (UK)Organization
The National Rheumatoid Arthritis Society on the gum-disease connection.
View source
Rheumatology AdvisorClinical overview
A clinical summary of the bi-directional links between rheumatoid arthritis and periodontal disease.
View source
Everyday HealthOverview
A plain-language overview of what patients should know about the RA and gum-disease link.
View source
Pneumonia & Respiratory4 sources
NIH / PMCJournal review
On how aspiration of oral bacteria may contribute to the progression of lower airway inflammation.
View source
CDCToolkit
The CDC oral-health toolkit for preventing pneumonia in healthcare settings.
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VA ResearchResearch
Veterans Affairs research on oral hygiene as a tool to reduce pneumonia.
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InstadonticsOverview
A review of the evidence on whether poor oral hygiene can lead to pneumonia.
View source
Videos for Professionals5 sources
TDMC (Clinical, Dr. Chuck)Video
Why heart surgeons ask patients to see a dentist before they operate, and the case for pre-surgical dental clearance.
Watch
TDMC (Founder's perspective)Video
What sparked Dr. Chuck's decades of work on the oral-systemic connection, in his own words.
Watch
Dr. Amy DoneenVideo
An expert tip on the oral-systemic link from a leading cardiovascular-prevention clinician.
Watch
Educational seriesVideo
A multi-part visual series on the spread of bacteria in periodontitis.
Watch
ExplainerVideo
A general overview of the oral-systemic connection.
Watch

Bring It Into the Room

Three ways physicians and dentists can use this with patients this week

01

Ask one new question

For a patient with high blood pressure, diabetes, or cardiovascular risk, ask when they last had a complete dental exam with X-rays. It takes seconds, and it often surfaces an untreated oral infection the patient never thought to mention.

02

Hand them the form

Give the patient dental-health assessment form to anyone whose systemic condition might be influenced by an oral infection. It gives them a reason to see a dentist and something concrete to hand over when they get there.

03

Make the referral loop real

Share a study from the library with the dentist or physician on the other side of your patient's care. The evidence has existed for years. What has been missing is the two providers actually talking to each other.

Submit Research Section

Found research we should add?

This library grows because clinicians send us what they find. If you know a study or article on the oral-systemic connection that other clinicians should be reading, send it over. We review every submission and add the relevant ones.

Submit a study
Curated by a dentist with 40 years in practice 40+ peer-reviewed and institutional sources No industry funding Independent 501(c)(3) nonprofit

Help Close the Gap

Medicine and dentistry have been practiced in isolation from each other for over a century

The evidence connecting oral health to the rest of the body already exists. What is missing is getting it in front of the clinicians who can act on it. That is the work of The Dental Medical Convergence, a donor-funded nonprofit you can help by sharing this library or supporting it directly.

Share With a Colleague

Send this evidence library to a physician or dentist you work with. A referral gap closes fastest when the recommendation comes from a trusted colleague.

Support the Mission

Every donation pays for the research curation, education, and outreach that move this evidence from the journals into real exam rooms.

Frequently Asked

Questions

Who curates this library?

The library is maintained by The Dental Medical Convergence, a nonprofit founded by Dr. Chuck Reinertsen, DMD, a dentist with more than forty years in practice and the author of Are Your Teeth Making You Sick?. Every source is reviewed before it is added, and clinicians are invited to submit studies for consideration.

Can I use the assessment form in my own practice?

The assessment form is free for any clinician to download, print, and use with patients, and no account or permission is required. If you would like printed copies for a clinic, contact us and we will help you get them.

Does an association prove that oral infection causes these conditions?

Not on its own. Much of this evidence describes associations and shared mechanisms that continue to be studied, and the research community is still working out cause and effect. We present the studies so you can weigh them yourself.

How do I suggest a study for the library?

Email your suggestion to AMA@TheDentalMedicalConvergence.org. We review every submission and add the relevant research to this page.

Is there a version of this for my patients?

Yes, our Resources for Patients page presents the same connection in plain language, with guides and videos you can point patients to directly.

This page is provided for professional education and reference. It is not clinical guidance and does not replace your own clinical judgment or current practice guidelines. Each source links straight to the original research so you can evaluate it on its own terms, and its inclusion here is not an endorsement of any specific claim. A large share of this evidence points to associations, not settled causation, and remains an active area of study.

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